Doble Kara began with the story of a poverty-stricken Laura (Mylene Dizon) who had no means of acquiring money for her dying mother’s medical treatment. Laura, who had no choice but to resort to prostitution due to desperation, was impregnated by a married man named Antonio Dela Rosa (Allen Dizon). Despite of what happened, Ishmael (Ariel Rivera) who has shown Laura true love, marries her, and steps in as the father of her two unborn children. On the same day of Laura's childbearing, Lucille (Carmina Villaroel), Antonio’s wife, too, gives birth to their child, Sofia. However, the couple’s daughter died shortly thereafter its delivery in consequence of its premature birth. As Antonio and Lucille grieve and mourn for their daughter’s early passing, Laura and Ishmael enjoyed and lived a happy life with their twin daughters, Kara and Sara (Julia Montes), regardless of being poor. However, when Kara was diagnosed with leukemia, the twins' parents was forced to separate the two and give up Kara to her biological father Antonio, who had the means to take care of her, because they don't have the money for her treatments. Unbeknownst to her of the existing relationship between her husband and Kara, Lucille adopts and brings Kara abroad where she recovers from her illness.
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