Doble Kara began with the story of a poverty-stricken Laura (Mylene Dizon) who had no means of acquiring money for her dying mother’s medical treatment. Laura, who had no choice but to resort to prostitution due to desperation, was impregnated by a married man named Antonio Dela Rosa (Allen Dizon). Despite of what happened, Ishmael (Ariel Rivera) who has shown Laura true love, marries her, and steps in as the father of her two unborn children. On the same day of Laura's childbearing, Lucille (Carmina Villaroel), Antonio’s wife, too, gives birth to their child, Sofia. However, the couple’s daughter died shortly thereafter its delivery in consequence of its premature birth. As Antonio and Lucille grieve and mourn for their daughter’s early passing, Laura and Ishmael enjoyed and lived a happy life with their twin daughters, Kara and Sara (Julia Montes), regardless of being poor. However, when Kara was diagnosed with leukemia, the twins' parents was forced to separate the two and give up Kara to her biological father Antonio, who had the means to take care of her, because they don't have the money for her treatments. Unbeknownst to her of the existing relationship between her husband and Kara, Lucille adopts and brings Kara abroad where she recovers from her illness. The two siblings, despite sharing the same appearance, grew up having two separate lives, and exhibit contrasting personalities. Sara, who has an extreme fondness of beauty contests and pageants, grew up ambitiously towards her own life and dream. While, Kara grew up to be charming, sweet, mellow, very sophisticated, and artistically inclined. As time passes, a grown-up Kara returned back to her hometown, and had made a strong resolution to herself to find her family, against her father’s wishes. While, Sara, on the other hand, remained ignorant of her sister's whereabouts, busy and determined to pursue her dream of becoming rich and famous. What will Sara and Kara do when fate brings them back together after many years? How will the sisters' relationship change after they grew up having different lives?
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